Nov 20, 2025

MDMA and Ketamine as Tools for Trauma Treatment: Reflections From an Expert in Both

Sandy Newes
Category: Podcasts
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Dr. Raymond Turpin is the Clinical and Executive Director of The Pearl Institute, a nonprofit organization dedicated to advancing trauma-informed care and psychedelic-assisted therapies. He has worked in psychiatric hospitals, psychiatric emergency units, residential treatment facilities, juvenile detention, schools, and community mental health clinics. Before The Pearl Institute, Dr. Turpin co-founded Jackson County Psychological Services, which provided free and reduced-cost mental health services to the students and families of the Jackson County Public School system.

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Here’s a glimpse of what you’ll learn:

  • [3:43] How Dr. Raymond Turpin’s first psilocybin experience in college led him to study psychedelics
  • [6:37] The early history of LSD research and how cultural backlash shut it down
  • [9:44] How the Grateful Dead shaped Dr. Turpin’s understanding of non-ordinary states
  • [13:29] Dr. Turpin’s path into MDMA research and the origins of The Pearl Institute
  • [19:54] Why Dr. Turpin believes trauma underlies most mental health conditions
  • [24:24] The shortcomings of current research protocols
  • [27:58] How MDMA reduces fear responses and enables deeper trauma work
  • [39:59] The Pearl Institute’s ketamine services and Dr. Turpin’s shift from skepticism to appreciation of the medicine
  • [47:47] The relational aspects of ketamine therapy and supporting client safety
  • [52:57] What makes effective trauma-focused psychedelic practitioners?

In this episode…

Psychedelic-assisted therapy is reshaping how clinicians understand trauma, resilience, and healing. With veterans, first responders, and countless others still struggling despite traditional treatments, many are wondering whether a different therapeutic pathway is finally within reach. What happens when medicine, neuroscience, and expanded states of consciousness converge? How can clinicians bring innovative treatments to people who need them most?

With decades of experience in trauma-focused psychology, Dr. Raymond Turpin believes that meaningful healing begins by accessing the deeper layers of the psyche that conventional talk therapy often can’t reach. He emphasizes the importance of preparation, safety, and intentional integration, noting that even profound non-ordinary experiences require commitment and follow-through to create transformation. Relational support, skilled guidance, and a willingness to engage with inner material can catalyze healing.

In this episode of Living Medicine, Dr. Sandy Newes talks with Dr. Raymond Turpin, Clinical and Executive Director of The Pearl Institute, about psychedelic-assisted trauma therapy. Dr. Turpin shares his path into MDMA research, how his team became an expanded access site treating four clients, and why his view of ketamine evolved through clinical experience.

Resources mentioned in this episode:

Quotable Moments:

  • “I was very curious about mushrooms in particular, and that experience really put me on this path.”
  • “I became curious, why are we not talking about these? Why did it just go away?”
  • “I learned a lot about the mind, and it was a wonderful 10 years of shows.”
  • “We were lucky enough to be able to get in on some of the MDMA work.”
  • “We know biologically what’s going on in the brain and what the healing mechanism is.”

Action Steps:

  1. Prioritize safety and trust in every session: Creating a secure therapeutic environment allows clients to relax, access deeper material, and fully engage in the healing process. When people feel safe, their nervous systems can shift out of protection and into meaningful psychological change.
  2. Strengthen preparation practices before psychedelic sessions: Thorough preparation helps clients understand intentions, anticipate emotional terrain, and approach the experience with clarity. This foundation increases the likelihood of productive insights and reduces anxiety going into non-ordinary states.
  3. Emphasize intentional integration as a non-negotiable step: Insights gained during MDMA or ketamine sessions require structured follow-through to become real-world change. Integration bridges the experience with actionable steps, improving long-term outcomes.
  4. Develop deep trauma competence as a core clinical skill: Most symptoms are rooted in poorly integrated trauma, so understanding its physiology and compensatory patterns is essential. Trauma-informed clinicians can more effectively guide clients through challenging material that surfaces during psychedelic work.
  5. Use relational attunement to enhance therapeutic depth: A grounded, attuned therapeutic relationship helps clients feel supported as they navigate vulnerable internal states. This connection amplifies the effectiveness of psychedelic-assisted therapy and increases client resilience during and after sessions.

Sponsor for this episode…

This episode is brought to you by the Living Medicine Institute.

LMI is a training, resource, and membership program educating providers about the legal and safe use of psychedelic-assisted psychotherapy.

To learn more or participate, visit https://livingmedicineinstitute.com.

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